General

Decoding Cancer Genes

I don’t think I’ve ever talked about medical stuff on my blog, but the complexity of the human body has always fascinated and confounded me. I never wanted to be a doctor, but my two cousins are brilliant doctor-researchers and they explain complex medical issues incredibly well and through them I have a sliver of a window into the world of medical academics.

The news that “researchers have decoded all the genes of a person with cancer and found a set of mutations that may have caused the disease or aided its progression” seems like an incredible leap forward in the understanding of cancer.

The new research, by looking at the entire genome — all the DNA — and aiming to find all the mutations involved in a particular cancer, differs markedly from earlier studies, which have searched fewer genes for individual mutations. The project, which took months and cost $1 million, was made possible by recent advances in technology that have made it easier and cheaper to analyze 100 million DNA snippets than it used to be to analyze 100.

The study was done at Washington University in St. Louis and is being published Thursday in the journal Nature. It is the first report of a “cancer genome,” and researchers say many more are to come.

Having the full genome decoded expands the pool of suspects dramatically… and that could change the way that cancers are treated.

Indeed, 8 of the 10 mutations his group found in the leukemia patient had never been linked to the disease before and would not have been found with the more traditional, “usual suspects” approach.

Despite all the years of research, I find it amazing that there is still so much that is not known about cancer. Forget cancer, but about the human body! It is completely understandable and completely frustrating at the same time. In fact the article talks about how they studied others with the same disease and none of them had the eight mutations of the first patient. So it seems like it will take a lot more effort and research to find the commonality that causes all the patients to start at different points but end up with the same disease.

Still, it seems to be a wonderful first step.

Dr. Wilson said he hoped that in 5 to 20 years, decoding a patient’s cancer genome would consist of dropping a spot of blood onto a chip that slides into a desktop computer and getting back a report that suggests which drugs will work best.

I hope that number is closer to the 5 year mark – for the sake of all those who suffer through cancer and for the families that love them.

Blog redesign – better than a spa day!

I’ve had the same basic WordPress K2 theme since I started this blog. It always felt basic, but I was fine with that. In contrast, Tatvam, designed by uber-designer George, was beautiful and elegant.

For the past few months though I started wanting a new, fresh look. I looked at the WordPress themes that were out there, but none of them really grabbed me. Then one day I saw a really unique illustration done by someone called MayG (Mahjabeen Umar). I dug a little deeper and found that MayG designs websites and has just started styling blogs.

MayG and I got to work. She asked me a whole bunch of questions to figure out who I was, what mattered to me and what kind of design aesthetic I wanted. She then cranked away and about four days later sprung what I consider an incredible illustration on me. It’s the multi-handed image that you see on the top left of the new blog design and it was love at first sight. The concept was cool and she did such a great job on the execution (in the process making my online avatar look better than reality!) And it really felt like even if I had a most basic theme, this illustration would set it apart.

But she was just getting started. Far from producing a basic theme, she designed something elegant and unique with style elements that are uncommon in blogs. At the same time she stuck to my requests for classy, elegant, clean and non-cutesy.

And voila! We have here Shripriya’s Post-It theme. It’s a theme that can change with me and morph as my life does. It makes me smile.

As MayG promised me early in the process – a blog redesign, when done right, can be better than a spa day. The past few weeks have been incredibly rough on the personal front and I need not just a spa day, but a full spa month! In fact, I actively sought distractions to help me get through things. Well this little redesign was definitely a step in the right direction.

I can’t say enough good things about working with MayG. She has the right balance of her own creativity and giving the client what she wants. She is incredibly talented and very responsive. She’s up on all the latest design trends and has informed opinions on what works and what doesn’t. And she hits the timelines she promises.

If you are thinking of redesigning your blog or just want a new avatar, MayG is your gal. I could not recommend her more highly.

In addition to having a new blog, I also have a new friend. What could be better?

The Gates Foundation

Say what you want about Bill Gates in his Microsoft avatar, but he is the most impressive philanthropist. By far.

The Gates Foundation is not futzing around handing nickles and dimes to every worthy cause out there. They are focused on the big picture – solving real issues (health) that affect millions if not billions of people.

In our lifetime, they will be responsible for eradication a major disease. That is just… mindblowing. It is humbling and empowering and gives me so much hope that money, used effectively, can have an incredible impact in the philanthropic realm.

Thank you Bill Gates.

UNITED NATIONS (Reuters) – Microsoft founder Bill Gates gave $168.7 million to develop vaccines for malaria, part of $3 billion in funding announced on Thursday to tackle Africa’s biggest killer disease.

Gates said the funding for the PATH Malaria Vaccine Initiative, in conjunction with GlaxoSmithKline Plc, will support “next-generation” vaccines research to find longer-lasting protection against the mosquito-borne disease.
Gates gives $168 mln for malaria vaccines research – Yahoo! News

Michael Phelps – #7 in pictures

For a whole bunch of reasons, I couldn’t be near a TV when Michael Phelps was swimming the 100M Butterfly for his seventh gold of the Olympics. But I really wanted him to win and, eager to know what happened, I called someone who gave me the play-by-play as it happened.

Once I got near a TV/computer, I watched the fantastic race and continued to stay amazed that the guy won.

It all comes down to the fact that Cavic took a long final stroke and “coasted” to the wall while Phelps took an extra stroke to hit the wall first. But if you want to be totally convinced, these pictures (from Sports Illustrated, where there are more images) will quench your thirst.

Phelps is on the left, bare chested; Cavic is on the right in the suit

As an aside, I find that being an American citizen for the first time during an Olympics has a marked bearing on my rooting for American atheletes.

Women at b-school

The March 2008 edition of the HBS Bulletin had a little piece about the first women MBA students.

“A ‘Daring Exper-iment’: Harvard and Busi-ness Education for Women, 1937–1970,” tells the story of how coeducation at HBS evolved from an eleven-month certificate program in “personnel administration” at Radcliffe College (1937–1945), to the Management Training Program (1946–1955), to the Harvard-Radcliffe Program in Business Administration (1956–1963) — the last step before complete integration took place with the admission of eight women into the MBA Class of 1965.

But what’s even more interesting is a letter to the editor that showed up in the current issue (June 2008) –

Your March article “A History of Women at HBS” omitted an important category — women in the early sixties who were not admitted to the firstyear at HBS. Instead, their only option was to attend a separate and unequal first-year class at the Harvard-Radcliffe Program in Business Administration, a nondegree program. The women were then allowed to apply for the second year at HBS, and fewer than ten were accepted. In the second-year program, they were given no housing or section designation, and a professor could deny entrance to his course.

When job interviews started on campus, women’s names were scratched from the interview list. Recruiters refused to interview them because it was a “waste of time.” I know, because this happened to me. I was part of this forgotten class.

Joan Oxman Rothberg

(HRPBA 1962, MBA ’63)

Summit, NJ

Wow – scratched off the interview list! Incredible how far we’ve come. And that’s an excellent thing.

Great Urban Race

Then came a crucial moment: the second scavenger-hunt clue was to either 1) get a $500 bill from Monopoly, or 2) get a picture of ten people within arms-reach of an ad for Grand Theft Auto IV. Chris knew of a toy store about a half-block off our path; I rushed in and was able to buy a pack of Monopoly money. (The GTA IV ads were all over the place, but we judged that getting 10 people to pose simultaneously would prove hard – the $500 bill ended up taking about 3 minutes and costing $4.32.)

This “The Game” stuff sounds like fun. Kind of like King’s Quest (a Role Playing Adventure computer game), but in real life. I wonder why I had no inkling this stuff existed when I was in the Bay Area… Probably because I am not geeky enough 🙂

Read Erik’s full report

Benny Lava is stuck in my head

I don’t think I’ve quite seen this before – some guy takes a Tamil song and does a transliteration – the subtitles are not the meaning of the song, but how it sounds to him in English. OMG!! Too funny.

I speak Tamil, so not all of it sounds close, but still worth watching… Thanks to Manish for sending.

From those to whom much is given, much is expected

There has been a lot of press about Steve Jobs’ inspirational “Stay Hungry. Stay Foolish” speech at Stanford’s Commencement in 2005. Deservedly so.

I think Bill Gates delivered a very different and equally brilliant speech at Harvard’s 2007 Commencement. I believe Bill Gates will make history outside of technology — The Gates Foundation’s focus on eradicating diseases will change the trajectory of countries, if not continents. I love how this speech focuses on giving back. He closes with this:

And I hope you will come back here to Harvard 30 years from now and reflect on what you have done with your talent and your energy. I hope you will judge yourselves not on your professional accomplishments alone, but also on how well you have addressed the world’s deepest inequities … on how well you treated people a world away who have nothing in common with you but their humanity.

Yes! So well said!! It makes my hair stand on end!

I recently visited Boston for my 10th year business school reunion. The metrics for how my classmates and I judge ourselves have changed so much since we were students. So, this speech, delivered just a few days after I was on campus resonates even more.

It is worth reading the whole thing and I have reproduced it below.

 

Remarks of Bill Gates

Harvard Commencement

(Text as prepared for delivery)

President Bok, former President Rudenstine, incoming President Faust, members of the Harvard Corporation and the Board of Overseers, members of the faculty, parents, and especially, the graduates:

I’ve been waiting more than 30 years to say this: “Dad, I always told you I’d come back and get my degree.”

I want to thank Harvard for this timely honor. I’ll be changing my job next year … and it will be nice to finally have a college degree on my resume.

I applaud the graduates today for taking a much more direct route to your degrees. For my part, I’m just happy that the Crimson has called me “Harvard’s most successful dropout.” I guess that makes me valedictorian of my own special class … I did the best of everyone who failed.

But I also want to be recognized as the guy who got Steve Ballmer to drop out of business school. I’m a bad influence. That’s why I was invited to speak at your graduation. If I had spoken at your orientation, fewer of you might be here today.

Harvard was just a phenomenal experience for me. Academic life was fascinating. I used to sit in on lots of classes I hadn’t even signed up for. And dorm life was terrific. I lived up at Radcliffe, in Currier House. There were always lots of people in my dorm room late at night discussing things, because everyone knew I didn’t worry about getting up in the morning. That’s how I came to be the leader of the anti-social group. We clung to each other as a way of validating our rejection of all those social people.

Radcliffe was a great place to live. There were more women up there, and most of the guys were science-math types. That combination offered me the best odds, if you know what I mean. This is where I learned the sad lesson that improving your odds doesn’t guarantee success.

One of my biggest memories of Harvard came in January 1975, when I made a call from Currier House to a company in Albuquerque that had begun making the world’s first personal computers. I offered to sell them software.

I worried that they would realize I was just a student in a dorm and hang up on me. Instead they said: “We’re not quite ready, come see us in a month,” which was a good thing, because we hadn’t written the software yet. From that moment, I worked day and night on this little extra credit project that marked the end of my college education and the beginning of a remarkable journey with Microsoft.

What I remember above all about Harvard was being in the midst of so much energy and intelligence. It could be exhilarating, intimidating, sometimes even discouraging, but always challenging. It was an amazing privilege – and though I left early, I was transformed by my years at Harvard, the friendships I made, and the ideas I worked on.

But taking a serious look back … I do have one big regret.

I left Harvard with no real awareness of the awful inequities in the world – the appalling disparities of health, and wealth, and opportunity that condemn millions of people to lives of despair.

I learned a lot here at Harvard about new ideas in economics and politics. I got great exposure to the advances being made in the sciences.

But humanity’s greatest advances are not in its discoveries – but in how those discoveries are applied to reduce inequity. Whether through democracy, strong public education, quality health care, or broad economic opportunity – reducing inequity is the highest human achievement.

I left campus knowing little about the millions of young people cheated out of educational opportunities here in this country. And I knew nothing about the millions of people living in unspeakable poverty and disease in developing countries.

It took me decades to find out.

You graduates came to Harvard at a different time. You know more about the world’s inequities than the classes that came before. In your years here, I hope you’ve had a chance to think about how – in this age of accelerating technology – we can finally take on these inequities, and we can solve them.

Imagine, just for the sake of discussion, that you had a few hours a week and a few dollars a month to donate to a cause – and you wanted to spend that time and money where it would have the greatest impact in saving and improving lives. Where would you spend it?

For Melinda and for me, the challenge is the same: how can we do the most good for the greatest number with the resources we have.

During our discussions on this question, Melinda and I read an article about the millions of children who were dying every year in poor countries from diseases that we had long ago made harmless in this country. Measles, malaria, pneumonia, hepatitis B, yellow fever. One disease I had never even heard of, rotavirus, was killing half a million kids each year – none of them in the United States.

We were shocked. We had just assumed that if millions of children were dying and they could be saved, the world would make it a priority to discover and deliver the medicines to save them. But it did not. For under a dollar, there were interventions that could save lives that just weren’t being delivered.

If you believe that every life has equal value, it’s revolting to learn that some lives are seen as worth saving and others are not. We said to ourselves: “This can’t be true. But if it is true, it deserves to be the priority of our giving.”

So we began our work in the same way anyone here would begin it. We asked: “How could the world let these children die?”

The answer is simple, and harsh. The market did not reward saving the lives of these children, and governments did not subsidize it. So the children died because their mothers and their fathers had no power in the market and no voice in the system.

But you and I have both.

We can make market forces work better for the poor if we can develop a more creative capitalism – if we can stretch the reach of market forces so that more people can make a profit, or at least make a living, serving people who are suffering from the worst inequities. We also can press governments around the world to spend taxpayer money in ways that better reflect the values of the people who pay the taxes.

If we can find approaches that meet the needs of the poor in ways that generate profits for business and votes for politicians, we will have found a sustainable way to reduce inequity in the world. This task is open-ended. It can never be finished. But a conscious effort to answer this challenge will change the world.

I am optimistic that we can do this, but I talk to skeptics who claim there is no hope. They say: “Inequity has been with us since the beginning, and will be with us till the end – because people just … don’t … care.” I completely disagree.

I believe we have more caring than we know what to do with.

All of us here in this Yard, at one time or another, have seen human tragedies that broke our hearts, and yet we did nothing – not because we didn’t care, but because we didn’t know what to do. If we had known how to help, we would have acted.

The barrier to change is not too little caring; it is too much complexity.

To turn caring into action, we need to see a problem, see a solution, and see the impact. But complexity blocks all three steps.

Even with the advent of the Internet and 24-hour news, it is still a complex enterprise to get people to truly see the problems. When an airplane crashes, officials immediately call a press conference. They promise to investigate, determine the cause, and prevent similar crashes in the future.

But if the officials were brutally honest, they would say: “Of all the people in the world who died today from preventable causes, one half of one percent of them were on this plane. We’re determined to do everything possible to solve the problem that took the lives of the one half of one percent.”

The bigger problem is not the plane crash, but the millions of preventable deaths.

We don’t read much about these deaths. The media covers what’s new – and millions of people dying is nothing new. So it stays in the background, where it’s easier to ignore. But even when we do see it or read about it, it’s difficult to keep our eyes on the problem. It’s hard to look at suffering if the situation is so complex that we don’t know how to help. And so we look away.

If we can really see a problem, which is the first step, we come to the second step: cutting through the complexity to find a solution.

Finding solutions is essential if we want to make the most of our caring. If we have clear and proven answers anytime an organization or individual asks “How can I help?,” then we can get action – and we can make sure that none of the caring in the world is wasted. But complexity makes it hard to mark a path of action for everyone who cares — and that makes it hard for their caring to matter.

Cutting through complexity to find a solution runs through four predictable stages: determine a goal, find the highest-leverage approach, discover the ideal technology for that approach, and in the meantime, make the smartest application of the technology that you already have — whether it’s something sophisticated, like a drug, or something simpler, like a bednet.

The AIDS epidemic offers an example. The broad goal, of course, is to end the disease. The highest-leverage approach is prevention. The ideal technology would be a vaccine that gives lifetime immunity with a single dose. So governments, drug companies, and foundations fund vaccine research. But their work is likely to take more than a decade, so in the meantime, we have to work with what we have in hand – and the best prevention approach we have now is getting people to avoid risky behavior.

Pursuing that goal starts the four-step cycle again. This is the pattern. The crucial thing is to never stop thinking and working – and never do what we did with malaria and tuberculosis in the 20th century – which is to surrender to complexity and quit.

The final step – after seeing the problem and finding an approach – is to measure the impact of your work and share your successes and failures so that others learn from your efforts.

You have to have the statistics, of course. You have to be able to show that a program is vaccinating millions more children. You have to be able to show a decline in the number of children dying from these diseases. This is essential not just to improve the program, but also to help draw more investment from business and government.

But if you want to inspire people to participate, you have to show more than numbers; you have to convey the human impact of the work – so people can feel what saving a life means to the families affected.

I remember going to Davos some years back and sitting on a global health panel that was discussing ways to save millions of lives. Millions! Think of the thrill of saving just one person’s life – then multiply that by millions. … Yet this was the most boring panel I’ve ever been on – ever. So boring even I couldn’t bear it.

What made that experience especially striking was that I had just come from an event where we were introducing version 13 of some piece of software, and we had people jumping and shouting with excitement. I love getting people excited about software – but why can’t we generate even more excitement for saving lives?

You can’t get people excited unless you can help them see and feel the impact. And how you do that – is a complex question.

Still, I’m optimistic. Yes, inequity has been with us forever, but the new tools we have to cut through complexity have not been with us forever. They are new – they can help us make the most of our caring – and that’s why the future can be different from the past.

The defining and ongoing innovations of this age – biotechnology, the computer, the Internet – give us a chance we’ve never had before to end extreme poverty and end death from preventable disease.

Sixty years ago, George Marshall came to this commencement and announced a plan to assist the nations of post-war Europe. He said: “I think one difficulty is that the problem is one of such enormous complexity that the very mass of facts presented to the public by press and radio make it exceedingly difficult for the man in the street to reach a clear appraisement of the situation. It is virtually impossible at this distance to grasp at all the real significance of the situation.”

Thirty years after Marshall made his address, as my class graduated without me, technology was emerging that would make the world smaller, more open, more visible, less distant.

The emergence of low-cost personal computers gave rise to a powerful network that has transformed opportunities for learning and communicating.

The magical thing about this network is not just that it collapses distance and makes everyone your neighbor. It also dramatically increases the number of brilliant minds we can have working together on the same problem – and that scales up the rate of innovation to a staggering degree.

At the same time, for every person in the world who has access to this technology, five people don’t. That means many creative minds are left out of this discussion — smart people with practical intelligence and relevant experience who don’t have the technology to hone their talents or contribute their ideas to the world.

We need as many people as possible to have access to this technology, because these advances are triggering a revolution in what human beings can do for one another. They are making it possible not just for national governments, but for universities, corporations, smaller organizations, and even individuals to see problems, see approaches, and measure the impact of their efforts to address the hunger, poverty, and desperation George Marshall spoke of 60 years ago.

Members of the Harvard Family: Here in the Yard is one of the great collections of intellectual talent in the world.

What for?

There is no question that the faculty, the alumni, the students, and the benefactors of Harvard have used their power to improve the lives of people here and around the world. But can we do more? Can Harvard dedicate its intellect to improving the lives of people who will never even hear its name?

Let me make a request of the deans and the professors – the intellectual leaders here at Harvard: As you hire new faculty, award tenure, review curriculum, and determine degree requirements, please ask yourselves:

Should our best minds be dedicated to solving our biggest problems?

Should Harvard encourage its faculty to take on the world’s worst inequities? Should Harvard students learn about the depth of global poverty … the prevalence of world hunger … the scarcity of clean water …the girls kept out of school … the children who die from diseases we can cure?

Should the world’s most privileged people learn about the lives of the world’s least privileged?

These are not rhetorical questions – you will answer with your policies.

My mother, who was filled with pride the day I was admitted here – never stopped pressing me to do more for others. A few days before my wedding, she hosted a bridal event, at which she read aloud a letter about marriage that she had written to Melinda. My mother was very ill with cancer at the time, but she saw one more opportunity to deliver her message, and at the close of the letter she said: “From those to whom much is given, much is expected.”

When you consider what those of us here in this Yard have been given – in talent, privilege, and opportunity – there is almost no limit to what the world has a right to expect from us.

In line with the promise of this age, I want to exhort each of the graduates here to take on an issue – a complex problem, a deep inequity, and become a specialist on it. If you make it the focus of your career, that would be phenomenal. But you don’t have to do that to make an impact. For a few hours every week, you can use the growing power of the Internet to get informed, find others with the same interests, see the barriers, and find ways to cut through them.

Don’t let complexity stop you. Be activists. Take on the big inequities. It will be one of the great experiences of your lives.

You graduates are coming of age in an amazing time. As you leave Harvard, you have technology that members of my class never had. You have awareness of global inequity, which we did not have. And with that awareness, you likely also have an informed conscience that will torment you if you abandon these people whose lives you could change with very little effort. You have more than we had; you must start sooner, and carry on longer.

Knowing what you know, how could you not?

And I hope you will come back here to Harvard 30 years from now and reflect on what you have done with your talent and your energy. I hope you will judge yourselves not on your professional accomplishments alone, but also on how well you have addressed the world’s deepest inequities … on how well you treated people a world away who have nothing in common with you but their humanity.

Good luck.